Novartis appoints James E. Bradner, MD as President of the Novartis Institutes for BioMedical Research as Mark Fishman retires

• New leader to continue to drive long-term innovation in Novartis research in wide range of therapeutic areas

Basel, September 24, 2015 - Novartis announced today that Dr. James (Jay) E. Bradner, physician-scientist from Dana-Farber Cancer Institute and Harvard Medical School, has been appointed President of the Novartis Institutes for BioMedical Research (NIBR) and a member of the Executive Committee of Novartis, effective March 1, 2016.

Dr. Bradner succeeds Mark C. Fishman, M.D., who will reach his contractual retirement age in March 2016 after a distinguished 13-year career at Novartis as the leader of the company's drug discovery and early clinical development efforts.

"Mark has done an outstanding job leading NIBR, and he will be missed. He redefined research at Novartis - recruiting top scientists and clinicians from around the world, putting patient need and disciplined science at the center of our strategy, which has filled our pipeline with new medicines," said Joseph Jimenez, CEO of Novartis.

"I am confident that Jay will continue this track record of success. He is an accomplished scientist whose discoveries in the area of chemical biology have revealed novel approaches for treating cancer and other illnesses. He is also an entrepreneur who has been the driving scientific force behind several biotech start-ups. His experience and perspectives make him a great fit to further develop our internal research capabilities, as well as expand our external collaboration efforts with biotech companies and academic institutions."

Dr. Bradner will be based at NIBR's global headquarters in Cambridge, Massachusetts and report to Joseph Jimenez, Chief Executive Officer of Novartis. He will join Novartis on January 1, 2016 to work alongside Dr. Fishman and the NIBR leadership team to ensure a smooth transition.

Dr. Bradner is on the faculty of Harvard Medical School in the Department of Medical Oncology at the Dana-Farber Cancer Institute. He is a graduate of Harvard College and the University of Chicago Medical School. He did his residency in medicine at the Brigham & Women's Hospital, and fellowship in Medical Oncology and Hematology at the Dana-Farber Cancer Institute, where he has been on the faculty since 2005. Dr. Bradner has co-authored more than 130 scientific publications and 30 United States Patent applications.

Disclaimer
The foregoing release contains forward-looking statements that can be identified by words such as "to continue," "long-term," "effective," "will," "confident," "to further develop . as well as expand," "to ensure," or similar terms, or by express or implied discussions regarding the potential impact of Dr. Fishman's retirement and of Dr. Bradner's leadership on Novartis. You should not place undue reliance on these statements. Such forward-looking statements are based on the current beliefs and expectations of management regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that Dr. Fishman's retirement and Dr. Bradner's appointment will have any particular impact on NIBR or Novartis. In particular, management's expectations could be affected by, among other things, the uncertainties inherent in research and development, including unexpected research or clinical trial results and additional analysis of existing data; unexpected regulatory actions or delays or government regulation generally; the company's ability to obtain or maintain proprietary intellectual property protection; general economic and industry conditions; global trends toward health care cost containment, including ongoing pricing pressures; unexpected manufacturing issues, and other risks and factors referred to in Novartis AG's current Form 20-F on file with the US Securities and Exchange Commission. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.

About Novartis
Novartis provides innovative healthcare solutions that address the evolving needs of patients and societies. Headquartered in Basel, Switzerland, Novartis offers a diversified portfolio to best meet these needs: innovative medicines, eye care and cost-saving generic pharmaceuticals. Novartis is the only global company with leading positions in these areas. In 2014, the Group achieved net sales of USD 58.0 billion, while R&D throughout the Group amounted to approximately USD 9.9 billion (USD 9.6 billion excluding impairment and amortization charges). Novartis Group companies employ approximately 120,000 full-time-equivalent associates. Novartis products are available in more than 180 countries around the world. For more information, please visit http://www.novartis.com.

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Jeffrey Lockwood
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